Molecular optimization using a conditional transformer for reaction-aware compound exploration with reinforcement learning

Abstract Designing molecules with desirable properties is a critical endeavor in drug discovery.Because of recent advances in deep learning, molecular generative models have been developed.However, the existing compound exploration models often disregard the important issue of ensuring the feasibility of organic synthesis.To address this issue, we

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Audio-visual interactions uniquely contribute to resolution of visual conflict in people possessing absolute pitch.

Individuals possessing absolute pitch (AP) are able to identify a given musical tone or to reproduce it without reference to another tone.The present study sought to learn whether this exceptional auditory ability Dry Bag impacts visual perception under stimulus conditions that provoke visual competition in the form of binocular rivalry.Nineteen ad

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Meningite bacteriana recorrente.

Recurrent bacterial meningitis (RBM) is an unusual entity and usually poses a considerable diagnostic challenge.Different conditions can predispose for recurrence of episodes and the isolated pathogen can guide the diagnosis.The Watch Accessory aim of this study was to characterize all RBM admitted to our tertiary paediatric hospital.Retrospective

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A thermodynamic platform for evaluating the energy efficiency of combined power generation and desalination plants

Abstract In seawater desalination, the energy efficiency of practical processes is expressed in kWh_electricity or low-grade-heat per m3 of water produced, omitting the embedded energy quality underlying their generation processes.To avoid thermodynamic misconceptions, it is important to recognize both quality and quantity of energy consumed.An unm

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